<img src="http://www.pcpowerplay.com.au/wp-content/uploads/2011/10/PCPP197Cover.jpg" alt="Krogan Blue is in vogue" width=450>
In the form of co-op, probably.
I'm not surprised, but I am a little disappointed. I don't care for multiplayer in general, but this means some of the resources that could have gone into making the game better have gone into making co-op. There might not be much overlap, but every bit counts.
Another reason it's a bit grating is that I have a deep connection with the Mass Effect setting games; the basic pointlessness of multiplayer (in PvP modes) or cognitive dissonance of co-op is at odds with the highly personal, directed nature of the story. It's not my right to demand anything from Bioware, I know, but I feel a little chagrined nevertheless.
On a side note, every little bit of gameplay information released is encouraging. Better gunplay, more customization, new powers, maneuverability. (I'm staying away from story spoilers.)
<i>Edit: "It shouldn’t be too much of a surprise – reports from inside EA have stated that EA wants multiplayer to be part of every single AAA title it releases, so we should have seen this one coming."
<a href="http://www.kotaku.com.au/2011/10/confirmed-mass-effect-3-will-have-multiplayer/">From Kotaku</a>
Well, we know how well that turned out for Dead Space 2.</i>
<strong>Edit: More info here.
It's looking good. Short version:
1. Co-op, separate from Shepard's story, same timeline, different part of the war with the Reapers
2. Create your character, play with three others as a squad in custom missions
3. Level/weapon progression
4. Co-op outcome can affect singleplayer ending--but ONLY IF YOU WANT IT TO.
5. Completely optional, created by Bioware Montreal, not Edmonton.
6. Not known if you can play with bots (and effectively extend your singleplayer playthrough)