I'm incredibly interested to see what happens with Dragon Age III; I think that there are a lot of direction that that one could go in.
On a more general front, I do hope that the most promising Kickstarter projects turn out well (as Duff noted this will be particularly interesting for Obsidian, as the lack of a publisher imposed deadline will really put their skills to the test. If I remember correctly, though, that wont be out next year, so whatever). I understand completely the people hoping for a huge failure from one/several of them, but the way I see it, more good games is a good thing.
I hope that Half Life 3 gets some kind of announcement, not because I enjoy the Half Life games (I don't), but because it would probably mean the announcement of a new Source engine, which is a far more exciting prospect in my opinion. Also, the release of Half Life 3 would theoretically allow Valve to focus more on other titles (and I do love their other games), though seeing as how they've released something like 5 games since the last Half Life instalment I don't think that its been slowing them down much.