I’ve been conservative with Vampire: The Masquerade – Bloodlines. The only modding I do is boshing on ye olde unofficial patch, without even enabling the optional new bits, and maybe replacing my character model with a nicer NPC model. I might be bolder next playthrough, as apparently we’re spoilt for choice with Bloodlines mods at the moment.
Mega-expand-o-overhaul Bloodlines Antitribu [official site] came out last week, with oodles of new clans, models, levels, weapons, skills, quests, characters, and so on. A new version of big overhaul mod The Final Nights [official forum] arrived too.