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Fallout 76 mutations: the best and worst mutations

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Not even an apple a day can prevent mutations, and while the mutations are hyper-unrealistic in the real world (you’re more likely to just die rather than grow a new appendage), Fallout 76 introduces new. So you’ll need to take different measures to prevent or cure any disease you may come into contact with. With the new mutations, it can be confusing as to which mutations are worth keeping and what the downsides may be. To that end, I’ve prepared this guide that will go over the best and worst mutations, and how to get rid of them if you wish.

Fallout 76 mutations guide

Those looking for a beginner’s guide to get started with the Fallout 76 beta and indeed the full game when it comes out should have a look at our Fallout 76 guide.

Easy ways to mutate

Avoiding mutation may be ideal for some people that want to keep their human as pure as possible, but for those who wish to alter their DNA, there are certain ways that you can expedite that process. These include:

  • Standing close to any hazardous waste.
  • Interacting with any of the petrified corpses.
  • Eating unpurified food or drinking water.
  • Swimming or standing in pools of water.
  • Breathing in noxious gasses.
  • Being attacked by toxic enemies or Feral Ghouls.

How long does a mutation last?

Mutations are almost permanent once you obtain them, with the only way to remove them entirely being to chug some Radaways. You can of course just expose yourself to more radiation to change your current mutation, however this just replaces one with another. Dying won’t remove your mutations, so if you have any mutations that you were hoping to keep, an untimely death won’t be a worry.

There is a perk however that allows you to keep your mutations. Starched Genes is unlocked at level 1 in Luck and at the second rank will ensure that you never mutate from rads and Radaway will never cure mutations. Therefore if you wish to have mutations in your build and want to ensure you never lose them, grab this perk and invest in it.

Known mutations and their effects

Now you know how about how to obtain the mutations, it’s best to know everything about the mutations that you can obtain in the game. Below is a table with all the mutations, as well as any positive or negative effects.

MutationPositive effectsNegative effects
Adrenal ReactionIncreased weapon damage and quick health regeneration at low HP.Maximum HP -50
Bird Bones+4 Intelligence. Falling from heights is more gradual.-4 Strength.
CarnivoreMeat provides double the benefits and no diseases.Cannot eat vegetables.
ChameleonWhile unarmoured and standing still; gain invisibility.
Eagle EyesCritical damage +25%.
+4 Perception.
-4 Strength.
Egg Head+6 Intelligence.-3 Strength.
-3 Endurance.
Electrically ChargedChance to shock melee attackers upon being hit.Small amount of damage is inflicted to the player.
Empath-25% damage taken by teammates.+33% damage taken by player.
Grounded100 Energy Resistence.-20% Energy damage.
Healing FactorHealth regeneration +300%.Chem effects -55%.
HerbivoreVegetables provide double the benefits and no diseases.Cannot eat meat.
Herd Mentality+2 to all SPECIAL stats when grouped.-2 to all SPECIAL stats when solo.
MarsupialCarry weight +20
Improved jump height.
-4 Intelligence.
Plague WalkerPoison aura scaling with your diseases (up to a ceiling of 4).Only active when diseased.
Scaly Skin+50 damage and energy resistance.-50 AP.
Speed Demon+20 movement speed.
Faster reload speed.
Hunger and thirst rates increased while moving.
TalonsPunching attacks deal 25% more damage and Bleed damage for 5 seconds.
-4 Agility
Twisted Muscles+25% melee damage. Better chance to cripple enemy limbs.-50% gun accuracy.
Unstable IsotopeChance to irradiate melee attackers with a small explosion when struck.Inflicts a small amount of damage to yourself. Some enemies are immune to the radiation effect.

Now you know about mutations, you should probably be made aware of diseases as well. They work very differently and are overwhelmingly negative, so head over to our Fallout 76 diseases guide to get the full list of diseases. You can also get perks via Perk Cards, which you can find out more about in our Fallout 76 perk cards guide since they work completely differently to just about any other Fallout game.

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Dave Irwin

Guides Writer

As guides writer for Rock, Paper, Shotgun, it is my privilege to understand how to play certain games well, so that newer players can understand the more complex things about them.

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