Providing more evidence for my "best" thesis, Massively has a fantastic story of loss and heartache in Eve Online. It's this kind of thing that made the game so thrilling to play, although never before on this scale. Player "stewie Zanjoahir" lost 213,000,000,000 ISK as he piloted an unfitted frigate through dangerous space, making it the biggest recorded loss in the game so far. The cash equivalent calculation can be made by reasoning that 213,000,000,000 ISK could be used to buy 367 PLEX codes with a real-world cash value of $6,422.50. What I would have given to read that chat log.
Here's the killboard link. Bizarrely CCP are unable to verify its authenticity for "privacy reasons". UPDATE: A couple of people have now pointed out that the other reason this might be awry is the blueprint costs, which might actually be a fraction of the killboard estimate. This could mean the real cost would be more like $200. A bit less exciting, but there we have it.