Given that the real place is slowly being swallowed by the Adriatic sea, Rise of Venice seems like a cruel title for a game. Why not just call it "Glug!"? Hold on, it turns out I am comedically mis-reading the title's intentions: Kalypso's Renaissance-set power-struggle is a historical strategy game. It's set back when being a sea merchant was an actual thing that could be a job, and you'll be engaging the twin tasks of earning money and attempting to gain influence over the City of Masks. The "Rise" is cultural. Swampy trailer beneath.
It's a time and place that seems particularly hostile: the Ottoman Empire is leaning in from the East, and pirates are massing in the Med. You're in the middle at the beginnings of a burgeoning empire. You'll need to sort out everything: the means of production and sea battles, to the more subtle strategies of political corruption and clandestine dealings using your own family members as emissaries. Your ultimate aim is to earn the respect of the 'Council of Ten', a group of elders who can transform a political career, and I'm guessing they like a bit of double dealing and backstabbing, Lannister-Style.
It'll be out this Autumnn.