Edge Online highlight the story of blind engineering student, Terry Garrett, who managed to complete the PC version Abe’s Exoddus using just audio-cues and the quick-save function. There's a video of Terry talking about his achievement, and playing the game, embedded below. He explains how he uses the various audio cues, such as stepping, running into a wall, falling, and so on, to navigate the levels and ultimately complete the game. It's an astonishing feat of aural exploration and imagination.
(And if ever there was a testament to the value of a PC gamer's quicksave function, this is it.)