The last we'd heard of sci-fi MMO Star Trek Online was that developers Perpetual Entertainment had been booted from the project. Now though it seems the project is back online. The Trekkie forums are alive with fans trying to figure out who has been brought in on the project, but all we have so far is that the site is still owned by CBS and some unfounded speculation that Cryptic (of City Of Heroes fame) are to be brought in. Cryptic would make a good candidate, if they hadn't already just announced a new MMO. I suppose they could make two MMOs at once, but I think that'd be unprecedented.
I think a decent crew-of-roaming-spaceship MMO could really work, but it's hard to imagine anyone breaking the mould of current MMO trends to make this the kind of game we'd all want to play.