The Binding of Isaac: Rebirth
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The Binding Of Isaac 2 "will happen" but not "any time soon", Edmund McMillen says
He's gotta finish Mewgenics first, for one thing
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The Binding Of Isaac's huge Repentance DLC is almost complete
"I have a feeling you're gunna sh*t your asses"
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Awesome Games Done Quick 2020 raised a whopping £2.3 million for charity
And here's a few more excellent PC speedruns you might have missed.