Nothing escapes the omniscient eye of the internet, and so it wasn't long before the hands-on Duke play at PAX was uploaded by winged technologists to our glowing rectangles. You can bear witness to some of the activities of the man in shades, below. It seems to be some kind of action game, focused on the use of firearms. The perspective, sensibly, is set from the view of the protagonist. There doesn't seem to be any way to talk to the monsters, aside from perhaps making some caustic quips that are basically rhetorical.
So yes. Duke footage.
Shake it, GameTrailers!