When R.U.S.E. is released in September, it will benefit from Valve’s Steamworks API to offer the best community experience to players. Consequently, a Steam account and Internet connection will be required to activate the game, as per Steam policy. For this reason, R.U.S.E. will not use the Ubisoft protection. Single player can be played offline.
Speculation about the end of UbiDRM ahoy! (Also thanks to everyone who sent in this link.)